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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11439309 B1

PDFFull Text
Date of Patent:
Sep. 13, 2022

Filed:

May. 07, 2012

Assessment of coronary heart disease with carbon dioxide

Applicants:

Rohan Dharmakumar, Moorpark, CA (US);

Debiao LI, San Marino, CA (US);

Sotirios A. Tsaftaris, Lucca, IT;

Inventors:

Rohan Dharmakumar, Moorpark, CA (US);

Debiao Li, San Marino, CA (US);

Sotirios A. Tsaftaris, Lucca, IT;

Assignee:

Cedars-Sinai Medical Center, Los Angeles, CA (US);

Attorneys:

Nixon Peabody LLP

Linda B. Huber

Suwei Zhu

Primary Examiner:

James M Kish

Int. Cl.
CPC ...
A61B 5/02 (2006.01); A61B 5/055 (2006.01); A61B 8/08 (2006.01); A61B 5/145 (2006.01); A61B 5/318 (2021.01); A61B 5/00 (2006.01); A61B 5/026 (2006.01); A61B 6/03 (2006.01); A61B 6/00 (2006.01); A61B 7/02 (2006.01); A61B 8/00 (2006.01); A61D 7/00 (2006.01); A61M 16/12 (2006.01); G01R 33/48 (2006.01); G01R 33/60 (2006.01);
U.S. Cl.
CPC ...
A61B 5/02007 (2013.01); A61B 5/0035 (2013.01); A61B 5/026 (2013.01); A61B 5/02028 (2013.01); A61B 5/055 (2013.01); A61B 5/145 (2013.01); A61B 5/318 (2021.01); A61B 6/032 (2013.01); A61B 6/4417 (2013.01); A61B 7/02 (2013.01); A61B 8/0883 (2013.01); A61B 8/4416 (2013.01); A61B 8/488 (2013.01); A61D 7/00 (2013.01); A61M 16/12 (2013.01); G01R 33/481 (2013.01); G01R 33/4806 (2013.01); G01R 33/4812 (2013.01); G01R 33/4814 (2013.01); G01R 33/60 (2013.01); A61B 5/7257 (2013.01); A61B 6/037 (2013.01); A61B 6/507 (2013.01); A61B 6/508 (2013.01);
Abstract

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI.

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