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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11434497 B1

PDFFull Text
Date of Patent:
Sep. 06, 2022

Filed:

Dec. 13, 2018

Recombinant influenza virus-like particles (vlps) produced in transgenic plants

Applicant:

Medicago Inc., Quebec, CA;

Inventors:

Marc-Andre D'Aoust, Quebec, CA;

Manon Couture, St. Augustin De Desmaures, CA;

Frederic Ors, Quebec, CA;

Sonia Trepanier, St. Nicolas, CA;

Pierre-Olivier Lavoie, Quebec, CA;

Michele Dargis, Quebec, CA;

Louis-Philippe Vezina, Neuville, CA;

Nathalie Landry, St.-Romuald, CA;

Assignee:

MEDICAGO INC., Quebec, CA;

Attorney:

ArentFox Schiff LLP

Primary Examiner:

Michelle S Horning

Int. Cl.
CPC ...
C12N 15/82 (2006.01); A61K 39/145 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 9/90 (2006.01); A61K 39/12 (2006.01); G06F 9/50 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8258 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 9/90 (2013.01); C12N 15/8257 (2013.01); C12Y 503/04001 (2013.01); G06F 9/505 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/543 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55583 (2013.01); A61K 2039/55588 (2013.01); A61K 2039/58 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12N 2760/16022 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16123 (2013.01); C12N 2760/16133 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16171 (2013.01); C12N 2760/16222 (2013.01); C12N 2760/16223 (2013.01); C12N 2760/16234 (2013.01); G06F 2209/508 (2013.01);
Abstract

A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

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