The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2022
Filed:
Mar. 14, 2019
Applicant:
Arcturus Therapeutics, Inc., San Diego, CA (US);
Inventors:
Assignee:
ARCTURUS THERAPEUTICS, INC., San Diego, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/11 (2013.01); A61K 48/00 (2013.01); C12N 2310/3513 (2013.01); C12N 2310/531 (2013.01);
Abstract
A synthetic transfer RNA with an extended anticodon loop. A synthetic suppressor transfer RNA useful for the treatment of a genetic disease like cystic fibrosis associated with a nonsense mutation. The synthetic transfer RNA contains an extended anticodon loop with two consecutive anticodon base triplets configured to base-pair to two consecutive codon base triplets on an mRNA. The first anticodon base triplet or the second anticodon base triplet is configured to base-pair to a stop codon base triplet on the mRNA.