The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2022
Filed:
May. 14, 2020
Applicant:
Provention Bio, Inc., Lebanon, NJ (US);
Inventors:
Francisco Leon, Bethesda, MD (US);
Kevan C. Herold, Norwalk, CT (US);
Jay S. Skyler, Key Biscayne, FL (US);
Assignee:
Provention Bio, Inc., Red Bank, NJ (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 3/10 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61P 3/10 (2018.01);
Abstract
Provided herein, in one aspect, is a method of preventing or delaying the onset of clinical type 1 diabetes (T1D), comprising: providing a non-diabetic subject who is at risk for T1D; determining that the non-diabetic subject (1) is substantially free of antibodies against zinc transporter 8 (ZnT8), (2) is HLA-DR4+, and/or (3) is not HLA-DR3+; and administering a prophylactically effective amount of an anti-CD3 antibody to the non-diabetic subject.