The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2022
Filed:
Nov. 02, 2012
Hanmi Science Co., Ltd, Hwaseong-si, KR;
Dae Jin Kim, Hwaseong-si, KR;
Myung Hyun Jang, Seoul, KR;
Seung Su Kim, Seoul, KR;
Jong Soo Lee, Seongnam-si, KR;
Jae Hyuk Choi, Seoul, KR;
Se Chang Kwon, Seoul, KR;
HANMI SCIENCE CO., LTD., Hwaseong-si, KR;
Abstract
A method for preparing a conjugate of a physiologically active polypeptide and a non-peptide polymer by linking physiologically active polypeptide with non-peptide polymer through a covalent bond using an organic solvent is provided. A method for preparing a physiologically active polypeptide complex by linking the conjugate with a carrier is provided. The complex shows improved in vivo duration and stability of the physiologically active polypeptide. The method can prepare the conjugate at a lower production cost, and the resulting conjugate shows an extension of in vivo activity at a relatively high level and significantly increase in the blood half-life.