The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Nov. 11, 2021
Applicant:

H. Lundbeck A/s, Valby, DK;

Inventors:

John J. M. Wiener, San Diego, CA (US);

Cheryl A. Grice, San Diego, CA (US);

Daniel J. Buzard, San Diego, CA (US);

Justin S. Cisar, San Diego, CA (US);

Olivia Delene Weber, San Diego, CA (US);

Amy Allan, San Diego, CA (US);

Nicholas Raffaele, San Diego, CA (US);

Jeanne Moody, San Diego, CA (US);

Michael B. Shaghafi, San Diego, CA (US);

Assignee:

H. LUNDBECK A/S, Valby, DK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07F 9/6558 (2006.01); C07D 401/14 (2006.01); A61P 25/04 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01); C07D 417/12 (2006.01); A61P 25/08 (2006.01); C07D 221/20 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 25/04 (2018.01); A61P 25/08 (2018.01); C07D 221/20 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07F 9/65583 (2013.01);
Abstract

Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.


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