The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Aug. 31, 2018
Applicants:

Basf SE, Ludwigshafen am Rhein, DE;

Symrise Ag, Holzminden, DE;

Inventors:

Benoît Join, Holzminden, DE;

Jekaterina Ongouta, Stadtoldendorf, DE;

Michael Backes, Holzminden, DE;

Rahim Brodhage, Höxter, DE;

Arnold Machinek, Holzminden, DE;

Hubert Loges, Höxter, DE;

Susanne Mundt, Holzminden, DE;

Tom Somers, Holzminden, DE;

Thomas Subkowski, Schriesheim, DE;

Jens Wittenberg, Limburgerhof, DE;

Martin Weisel, Mannheim, DE;

Wolfgang Siegel, Limburgerhof, DE;

Claus Bollschweiler, Heidelberg, DE;

Ralf Pelzer, Fürstenberg, DE;

Assignees:

BASF SE, Ludwigshafen am Rhein, DE;

SYMRISE AG, Holzminden, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 317/46 (2006.01); C07C 323/41 (2006.01); C07D 405/12 (2006.01); C07D 213/75 (2006.01); C07D 231/40 (2006.01); C07D 407/12 (2006.01); C07D 307/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 405/14 (2006.01); A61K 8/49 (2006.01); A61K 8/46 (2006.01); A61Q 11/00 (2006.01); A23L 29/00 (2016.01); A23L 27/00 (2016.01); A23G 3/36 (2006.01);
U.S. Cl.
CPC ...
C07D 317/46 (2013.01); A23G 3/36 (2013.01); A23L 27/88 (2016.08); A23L 29/035 (2016.08); A23L 29/045 (2016.08); A23L 29/055 (2016.08); A61K 8/46 (2013.01); A61K 8/494 (2013.01); A61K 8/4926 (2013.01); A61K 8/4973 (2013.01); A61K 8/4986 (2013.01); A61Q 11/00 (2013.01); C07C 323/41 (2013.01); C07D 213/75 (2013.01); C07D 231/40 (2013.01); C07D 307/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); A23V 2002/00 (2013.01);
Abstract

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.


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