The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2022
Filed:
Jul. 17, 2018
Zhejiang Huahai Pharmaceutical Co., Ltd, Taizhou, CN;
Xiaohui Zhou, Taizhou, CN;
Xiaoren Zhu, Taizhou, CN;
Yuanxun Zhu, Taizhou, CN;
Peng Dong, Taizhou, CN;
Peng Wang, Taizhou, CN;
Jinsheng Lin, Taizhou, CN;
Wenquan Zhu, Taizhou, CN;
Min Li, Taizhou, CN;
Zhejiang Huahai Pharmaceutical Co., Ltd, Taizhou, CN;
Abstract
A method for synthesizing valsartan, comprising the steps of: synthesizing a valsartan methyl ester intermediate to obtain a reaction mixture of the valsartan methyl ester intermediate; diluting the reaction mixture by salt water or water, and then using a first extraction solvent to extract the valsartan methyl ester intermediate; adding alkali to an organic layer containing the valsartan methyl ester intermediate for hydrolyzing, removing the organic layer, regulating pH of a water layer to be acidic by using acid, using the first extraction solvent to extract, concentrating a part of solvent, or distilling the solvent to dryness, and then adding a new solvent; finally, crystallizing, filtering, and drying to obtain the valsartan.