The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Dec. 18, 2017
Applicant:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventors:

Hans-Georg Lerchen, Leverkusen, DE;

Anne-Sophie Rebstock, Champagne au Mont d'Or, FR;

Beatrix Stelte-Ludwig, Wülfrath, DE;

Dennis Kirchhoff, Berlin, DE;

Sandra Berndt, Hohen Neuendorf, DE;

Lisa Dietz, Wuppertal, DE;

Stephan Märsch, Cologne, DE;

Stefanie Hammer, Berlin, DE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/65 (2017.08); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01);
Abstract

Specific binder-drug conjugates (ADCs) of kinesin spindle protein inhibitors, effective metabolites of these ADCs, processes for preparing these ADCs, the use of these ADCs for the treatment and/or prevention of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases, are described.


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