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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11433068 B1

PDFFull Text
Date of Patent:
Sep. 06, 2022

Filed:

Sep. 07, 2017

Treatment of cancers having alterations within the swi/snf chromatin remodeling complex

Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

David E. Fisher, Newton, MA (US);

Qing Yu Weng, Brookline, MA (US);

Shinichiro Kato, Brookline, MA (US);

Assignee:

THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);

Attorneys:

Nixon Peabody LLP

David S. Resnick

Jeanne Jodoin

Primary Examiner:

Craig D Ricci

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 31/404 (2006.01); A61K 31/55 (2006.01); A61K 31/711 (2006.01); A61K 31/542 (2006.01); A61P 35/00 (2006.01); A61K 31/277 (2006.01); A61K 31/4995 (2006.01); A61K 31/7105 (2006.01); C12Q 1/6827 (2018.01);
U.S. Cl.
CPC ...
A61K 31/4985 (2013.01); A61K 31/277 (2013.01); A61K 31/404 (2013.01); A61K 31/4995 (2013.01); A61K 31/542 (2013.01); A61K 31/55 (2013.01); A61K 31/711 (2013.01); A61K 31/7105 (2013.01); A61P 35/00 (2018.01); C12Q 1/6827 (2013.01);
Abstract

This disclosure provides compositions and methods of treating cancer by inhibiting histone methyltransferases alone or in combination by synergistically inhibiting a histone demethylase, or a histone deacetylase (HDAC), or a bromodomain (BRD)-containing protein, or a B-Raf kinase. In particular, the cancers have deficient of SWI/SNF chromatin remodeling complexes because of mutations in one or more of the complex's subunit members.

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Fisher, David. (2022). Treatment of cancers having alterations within the swi/snf chromatin remodeling complex (U.S. Patent No. 11433068). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11433068

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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