The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Sep. 27, 2018
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Tesfaye Biftu, Freehold, NJ (US);

Xianhai Huang, Warren, NJ (US);

Weiguo Liu, Princeton, NJ (US);

Weidong Pan, Hillsborough, NJ (US);

Min Park, Whippany, NJ (US);

Alexander Pasternak, Jamaica Plain, MA (US);

Wanying Sun, Edison, NJ (US);

Haifeng Tang, Metuchen, NJ (US);

Yi Zang, Princeton, NJ (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/353 (2006.01); A61K 31/397 (2006.01); A61K 31/427 (2006.01); A61P 31/04 (2006.01); A61K 31/4425 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/427 (2013.01); A61K 31/4425 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61P 31/04 (2018.01); C07D 417/14 (2013.01);
Abstract

The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.


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