The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 06, 2022

Filed:

Nov. 10, 2020
Applicant:

Micropure, Inc., Scottsdale, AZ (US);

Inventors:

Jaiprakash G. Shewale, Cave Creek, AZ (US);

William E. Cooley, Wyoming, OH (US);

James L. Ratcliff, Scottsdale, AZ (US);

Esmeralda Ann Garcia-Smith, Centerton, AR (US);

Assignee:

Micropure, Inc., Scottsdale, AZ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 8/20 (2006.01); A61K 8/44 (2006.01); A61Q 11/00 (2006.01); A61K 8/21 (2006.01); A61K 8/24 (2006.01); A61K 8/29 (2006.01); A61K 8/25 (2006.01); A61K 8/9789 (2017.01); A61K 8/34 (2006.01); A61K 8/60 (2006.01); A61K 8/06 (2006.01); A61K 8/19 (2006.01);
U.S. Cl.
CPC ...
A61K 8/20 (2013.01); A61K 8/06 (2013.01); A61K 8/19 (2013.01); A61K 8/21 (2013.01); A61K 8/24 (2013.01); A61K 8/25 (2013.01); A61K 8/29 (2013.01); A61K 8/34 (2013.01); A61K 8/442 (2013.01); A61K 8/60 (2013.01); A61K 8/9789 (2017.08); A61Q 11/00 (2013.01); A61K 2800/43 (2013.01); A61K 2800/48 (2013.01); A61K 2800/52 (2013.01); A61K 2800/92 (2013.01);
Abstract

Described herein are single-phase compositions and methods for its pharmaceutical and cosmetic use, comprising (i) a combination of N-acyl sarcosinate, (ii) an oxidative compound, and (iii) a buffering system in amounts and embodiments effective to protect the oxidative compounds from degradation prior to use and upon use and to enhance the efficacy of the composition in removing polymicrobial biofilms, reducing the re-growth of polymicrobial biofilms that leads to plaque formation, greater availability of chlorite ion for antimicrobial and cosmetic purposes, and effective oxidation of salivary biomolecules. When these single-phase compositions are comprised of a source of fluoride ion, they also achieve enhanced enamel fluoride uptake, higher enamel protection by enhanced remineralization and reduced demineralization of teeth when compared to US Pharmacopoeia Reference Dentifrice, prior known toothpastes comprising stabilized chlorine dioxide and comparable commercial dentifrices.


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