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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11432537 B1

PDFFull Text
Date of Patent:
Sep. 06, 2022

Filed:

Jun. 20, 2016

Method for producing blood chimeric animal

Applicants:

National Federation of Agricultural Cooperative Associations, Tokyo, JP;

The University of Tokyo, Tokyo, JP;

Inventors:

Kazuo Fukawa, Kato-gun, JP;

Tetsuya Ito, Kato-gun, JP;

Mai Kamikawa, Kato-gun, JP;

Yutaka Sendai, Tsukuba, JP;

Hiromitsu Nakauchi, Tokyo, JP;

Satoshi Yamazaki, Tokyo, JP;

Motoo Watanabe, Tokyo, JP;

Assignees:

THE UNIVERSITY OF TOKYO, Tokyo, JP;

NATIONAL FEDERATION OF AGRICULTURAL COOPERTIVE ASSOCIATIONS, Tokyo, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Christopher M Babic

Assistant Examiner:

Kimberly A Aron

Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/09 (2006.01); C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
A01K 67/0271 (2013.01); A01K 67/027 (2013.01); C12N 5/0647 (2013.01); C12N 15/09 (2013.01); A01K 2207/12 (2013.01); A01K 2217/052 (2013.01); A01K 2227/108 (2013.01); A01K 2267/025 (2013.01); C12N 2510/00 (2013.01); C12N 2510/02 (2013.01); C12N 2517/02 (2013.01);
Abstract

The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal at a high percentage is sustained for a long period of time. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified, The gene that acts on the hematopoietic system is, for example, Lnk gene, When a medium to large mammal is used as a recipient, the survival rate of hematopoietic cells originating in a heterologous animal is dramatically increased such that blood chimerism of 10% or more can be maintained even in a 16 month old animal.

Find Patent Forward Citations

Fukawa, Kazuo. (2022). Method for producing blood chimeric animal (U.S. Patent No. 11432537). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11432537

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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