Correction method for quantification accuracy improvement in list mode reconstruction

Abstract

A non-transitory computer-readable medium stores instructions readable and executable by a workstation () including at least one electronic processor () to perform an image reconstruction method () to reconstruct list mode data acquired over a frame acquisition time using a plurality of radiation detectors () in which the events of the list mode data is timestamped. The method includes: for the sub-frame bins of a plurality of sub-frame bins into which the frame acquisition time is divided, determining a sub-frame singles rates map for the plurality of radiation detectors from the list mode data whose time stamps reside in the sub-frame bin; determining a singles rate for the singles events of the list mode data using the sub-frame singles rates maps wherein the singles rates for the singles events are determined at a temporal resolution that is finer than the frame acquisition time; determining correction factors for the list mode data using the determined singles rates for the singles events of the list mode data; and reconstructing the list mode data of the frame acquisition time using the determined correction factors to generate a reconstructed image for the frame acquisition time.