The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
May. 05, 2017
Massachusetts Institute of Technology, Cambridge, MA (US);
Sangeeta N. Bhatia, Lexington, MA (US);
Gabriel A. Kwong, Atlanta, GA (US);
Piyush K. Jain, Somerville, MA (US);
Jaideep S. Dudani, Boston, MA (US);
Simone Schurle, Zurich, CH;
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present disclosure relates to methods and products associated with in vitro and in vivo protease activity measurements and enzyme profiling. Some aspects of the present disclosure relate to measuring remotely triggered protease activity. In particular, the disclosure relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence or absence of active enzymes associated with disease or conditions. The disclosure also relates to products, kits, and databases for use in the methods of the disclosure.