The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Apr. 11, 2018
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Université D'evry-val-d'essonne, Evry, FR;
Genethon, Evry, FR;
Fondazione Istituto Italiano Di Tecnologia, Genoa, IT;
Fondazione Telethon, Rome, IT;
Federico Mingozzi, Paris, FR;
Giuseppe Ronzitti, Paris, FR;
Andrea Contestabile, Genoa, IT;
Laura Cancedda, Genoa, IT;
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, Paris, FR;
UNIVERSITE D'EVRY-VAL-D'ESSONNE, Evry, FR;
GENETHON, Evry, FR;
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, Genoa, IT;
FONDAZIONE TELETHON, Rome, IT;
Abstract
An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.