The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Apr. 13, 2018
Applicant:
Tosoh Corporation, Yamaguchi, JP;
Inventors:
Yosuke Terao, Kanagawa, JP;
Naoki Yamanaka, Kanagawa, JP;
Natsuko Kizu, Kanagawa, JP;
Satoshi Endo, Kanagawa, JP;
Seigo Oe, Kanagawa, JP;
Assignee:
TOSOH CORPORATION, Yamaguchi, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/14 (2006.01); C07K 1/22 (2006.01); B01D 15/38 (2006.01); C07K 14/735 (2006.01); C07K 16/00 (2006.01); C12N 15/09 (2006.01); G01N 33/68 (2006.01); C12N 15/70 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
C12N 15/70 (2013.01); C07K 1/14 (2013.01); C07K 14/435 (2013.01); C07K 2317/52 (2013.01);
Abstract
The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid.