The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Apr. 10, 2018
Arbutus Biopharma Corporation, Burnaby, CA;
James Heyes, Vancouver, CA;
Richard J. Holland, Vancouver, CA;
Adam Judge, Bainbridge Island, WA (US);
Amy C. H. Lee, Burnaby, CA;
Alan D. Martin, Vancouver, CA;
Nicholas Michael Snead, San Francisco, CA (US);
Emily P. Thi, Coquitlam, CA;
Mark Wood, Port Moody, CA;
Xin Ye, Richmond, CA;
ARBUTUS BIOPHARMA CORPORATION, Burnaby, CA;
Abstract
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).