The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Jan. 30, 2020
Applicant:
Deep Genomics Incorporated, Toronto, CA;
Inventors:
Daniele Merico, Toronto, CA;
Joao Antonio Lourenco Goncalves, Toronto, CA;
Erno Wienholds, Toronto, CA;
Mark George Ford Sun, Toronto, CA;
Assignee:
DEEP GENOMICS INCORPORATED, Toronto, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/0019 (2013.01); A61K 45/06 (2013.01); C12N 2310/11 (2013.01); C12N 2310/314 (2013.01); C12N 2310/321 (2013.01); C12N 2310/346 (2013.01); C12N 2320/33 (2013.01);
Abstract
The present disclosure provides compositions and methods for treating a disorder associated with mutations in the CEP290 gene. The disclosure includes synthetic polynucleotides for skipping a reading-frame of a CEP290 pre-RNA, yielding a CEP290 translated product that lacks one or more exons. The disclosure also provides methods of treating patients with the synthetic polynucleotides disclosed herein.