The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Jun. 20, 2019
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Harold B. Wood, Westfield, NJ (US);
Hubert B. Josien, Jersey City, NJ (US);
Thomas Joseph Tucker, North Wales, PA (US);
Angela Dawn Kerekes, Plainfield, NJ (US);
Ling Tong, Warren, NJ (US);
Abbas M. Walji, Lansdale, PA (US);
Anilkumar G. Nair, Rahway, NJ (US);
Fa-Xiang Ding, Staten Island, NJ (US);
Elisabetta Bianchi, Rome, IT;
Danila Branca, Pomezia, IT;
Chengwei Wu, Ambler, PA (US);
Yusheng Xiong, Plainsboro, NJ (US);
Sookhee Nicole Ha, Warren, NJ (US);
Jian Liu, Edison, NJ (US);
Sobhana Babu Boga, Karnataka, IN;
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R, Rand Rare as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.