The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2022
Filed:
Jan. 05, 2018
The Johns Hopkins University, Baltimore, MD (US);
Institute of Organic Chemistry and Biochemistry As CR V.v.i., Prague, CZ;
Barbara Slusher, Kingsville, MD (US);
Camilo Rojas, Baltimore, MD (US);
Ajit G. Thomas, Baltimore, MD (US);
Radim Nencka, Roztoky, CZ;
Michal Sala, Kladno, CZ;
Hubert Hrebabecky, Prague, CZ;
Norman Haughey, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Institute of Organic Chemistry & Biochemistry, Prague, CZ;
Abstract
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), HIV-associated neurocognitive disorder (HAND), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS), and, in other aspects, for treating cancer, are provided.