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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11426454 B1

PDFFull Text
Date of Patent:
Aug. 30, 2022

Filed:

Jul. 01, 2019

Tuberculosis vaccine, preparation method therefor, and use thereof

Applicant:

Sichuan University, Chengdu, CN;

Inventors:

Zhenling Wang, Chengdu, CN;

Yuquan Wei, Chengdu, CN;

Assignee:

Sichuan University, Chengdu, CN;

Attorneys:

JCIP

Joseph G. Chu

Jeremy I. Maynard

Primary Examiner:

Gary B Nickol

Assistant Examiner:

Lakia J Jackson-Tongue

Int. Cl.
CPC ...
C12N 1/00 (2006.01); C12N 1/12 (2006.01); C12N 1/20 (2006.01); A61K 39/04 (2006.01); A61K 39/015 (2006.01); A61K 39/02 (2006.01); A61P 31/06 (2006.01); A61K 9/00 (2006.01); A61K 31/4409 (2006.01); A61K 31/496 (2006.01); A61K 31/7036 (2006.01); C12N 13/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/04 (2013.01); A61K 9/007 (2013.01); A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/0053 (2013.01); A61K 31/4409 (2013.01); A61K 31/496 (2013.01); A61K 31/7036 (2013.01); A61P 31/06 (2018.01); C12N 1/20 (2013.01); C12N 13/00 (2013.01); A61K 2039/521 (2013.01); A61K 2039/54 (2013.01); A61K 2039/542 (2013.01); A61K 2039/543 (2013.01); A61K 2039/544 (2013.01);
Abstract

The present invention relates to the field of tuberculosis vaccines, and specifically relates to a tuberculosis vaccine, a preparation method thereof, and a use thereof. To address the problem of existing vaccines being unsuitable for patients having weak immunity, the present invention provides a preparation method for a tuberculosis vaccine: first obtainingsingle cell bacteria, and using low dosage radiation to irradiate periodically thesingle cell bacteria, so as to obtain the tuberculosis vaccine. The present invention completely retains all of the antigen characteristics of the bacteria, and can more rapidly stimulate stronger specific immune responses, thereby achieving effective and long-lasting immunity. The vaccine prepared using the present invention has low toxicity, is rapid-acting and safer, and can be used for the prevention and treatment of tuberculosis for people having immunodeficiency.

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