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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11426397 B1

PDFFull Text
Date of Patent:
Aug. 30, 2022

Filed:

Mar. 26, 2018

Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6

Applicant:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

Jason Green, San Diego, CA (US);

Maria Hopkins, San Diego, CA (US);

Benjamin Jones, San Diego, CA (US);

Andre A. Kiryanov, San Diego, CA (US);

Jon Kuehler, San Diego, CA (US);

Holger Monenschein, San Diego, CA (US);

Sean Murphy, San Diego, CA (US);

Thomas Nixey, San Diego, CA (US);

Huikai Sun, San Diego, CA (US);

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED, Osaka, JP;

Attorneys:

McCarter & English, LLP

Michael J. DeGrazia

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
C07D 417/12 (2006.01); A61K 31/4545 (2006.01); A61K 31/198 (2006.01); A61K 31/451 (2006.01); A61K 31/4525 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5365 (2006.01); A61K 31/553 (2006.01); C07D 211/52 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 31/198 (2013.01); A61K 31/451 (2013.01); A61K 31/454 (2013.01); A61K 31/4525 (2013.01); A61K 31/4535 (2013.01); A61K 31/496 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5365 (2013.01); A61K 31/553 (2013.01); C07D 211/52 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R, R, R, R, R, X, X, X, X, X, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

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