The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Aug. 14, 2018
Applicant:
The University of Tokyo, Tokyo, JP;
Inventors:
Motoharu Seiki, Tokyo, JP;
Naohiko Koshikawa, Tokyo, JP;
Assignee:
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); G01N 33/50 (2006.01); C12N 15/113 (2010.01); C07K 14/715 (2006.01); A61K 31/713 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5011 (2013.01); A61K 31/713 (2013.01); C07K 14/715 (2013.01); C07K 16/2866 (2013.01); C07K 16/30 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); G01N 33/5023 (2013.01); G01N 33/574 (2013.01); C12N 2310/14 (2013.01); G01N 2333/912 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract
An object of the present invention is to elucidate a molecular mechanism of ligand-independent activation of EphA2 in cancer cells, make EphA2 a more useful target in the treatment of cancer, and provide a cancer testing method and the like using the mechanism. The present invention provides, for example, a cancer testing method including a step of measuring an amount of an EphA2 protein fragment having a molecular weight of from 30 kDa to 80 kDa in a sample derived from a subject.