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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11422074 B1

PDFFull Text
Date of Patent:
Aug. 23, 2022

Filed:

Jul. 06, 2015

Lossless cryo-grid preparation stage for high-resolution electron microscopy

Applicant:

Universität Basel, Basel, CH;

Inventors:

Stefan Alexander Arnold, Basel, CH;

Thomas Braun, Munchenstein, CH;

Henning Stahlberg, Binningen, CH;

Assignee:

UNIVERSITAT BASEL, Basel, CH;

Attorney:

JMB Davis Ben-David

Primary Examiner:

Benjamin R Whatley

Assistant Examiner:

Curtis A Thompson

Int. Cl.
CPC ...
G01N 1/42 (2006.01); H01J 37/20 (2006.01); G01N 1/28 (2006.01); H01J 37/26 (2006.01); G21K 5/10 (2006.01); G01D 3/00 (2006.01); G01D 7/00 (2006.01); A61K 9/127 (2006.01); C12Q 1/00 (2006.01); C12M 1/34 (2006.01); C12Q 1/68 (2018.01); B01L 9/06 (2006.01); G01N 1/06 (2006.01); G01N 1/04 (2006.01); G01N 1/44 (2006.01);
U.S. Cl.
CPC ...
G01N 1/42 (2013.01); H01J 37/20 (2013.01); A61K 9/127 (2013.01); B01L 9/06 (2013.01); C12M 1/34 (2013.01); C12Q 1/00 (2013.01); C12Q 1/68 (2013.01); G01D 3/00 (2013.01); G01D 7/00 (2013.01); G01N 1/04 (2013.01); G01N 1/06 (2013.01); G01N 1/28 (2013.01); G01N 1/2813 (2013.01); G01N 1/44 (2013.01); G21K 5/10 (2013.01); H01J 37/26 (2013.01); H01J 37/261 (2013.01); H01J 2237/002 (2013.01);
Abstract

The invention relates to a preparation system and method for preparing a sample for electron microscopy, the preparation system comprising: a liquid handling system () comprising a dispensing head (), wherein said liquid handling system () is configured to aspirate and dispense a volume of a sample via the dispensing head (), a support structure () that is configured to accommodate the sample, a temperature-controlled stage () that is configured to keep said support structure () at a pre-defined temperature, a first adapter () configured to hold said support structure (), and a transfer mechanism () that is configured to be connected to the first adapter () holding the support structure () and to move said support structure () into a container () containing a liquid cryogen () so that the sample on the support structure () contacts the cryogen ().

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