The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Jun. 22, 2020
Macrogenics, Inc., Rockville, MD (US);
Duke University, Durham, NC (US);
Scott Koenig, Rockville, MD (US);
Leslie S. Johnson, Rockville, MD (US);
Chia-Ying Kao Lam, Foster City, CA (US);
Liqin Liu, Germantown, MD (US);
Jeffrey Lee Nordstrom, Olney, MD (US);
Barton F. Haynes, Durham, NC (US);
Guido Ferrari, Durham, NC (US);
MacroGenics, Inc., Rockville, MD (US);
Duke University, Durham, NC (US);
Abstract
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.