The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
May. 18, 2018
Applicant:
Modernatx, Inc., Cambridge, MA (US);
Inventors:
Ankita Mishra, Cambridge, MA (US);
Joshua Frederick, Charlestown, MA (US);
Sushma Gurumurthy, Sharon, MA (US);
Assignee:
ModernaTX, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/54 (2006.01); A61K 9/51 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5434 (2013.01); A61K 9/5123 (2013.01); A61K 38/00 (2013.01); C07K 2319/03 (2013.01);
Abstract
The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain. The present disclosure also relates to vectors comprising the polynucleotides; host cells comprising the polynucleotides or vectors, polypeptides encoded by the polynucleotides; compositions comprising the polynucleotides, vectors, host cells, or polypeptides and a delivery agent; and uses thereof, including treatment of cancer.