The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Aug. 06, 2018
Applicant:
Heidelberg Pharma Research Gmbh, Ladenburg, DE;
Inventors:
Werner Simon, Ladenburg, DE;
Susanne Werner-Simon, Ladenburg, DE;
Christian Lutz, Ladenburg, DE;
Christoph Müller, Ladenburg, DE;
Torsten Hechler, Ladenburg, DE;
Michael Kulke, Ladenburg, DE;
Assignee:
Heidelberg Pharma Research GmbH, Ladenburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 47/68 (2017.01); C07K 1/06 (2006.01); C07K 7/64 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 47/6831 (2017.08); A61P 35/00 (2018.01); C07K 1/063 (2013.01); C07K 7/64 (2013.01);
Abstract
The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6' of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6′ of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.