The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Aug. 06, 2019
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Shanghai Syncores Technologies Inc. Ltd., Shanghai, CN;
Wenjing Liao, Shanghai, CN;
Jianfeng Ge, Zhejiang, CN;
Jicheng Zhang, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Eric Gu, Shanghai, CN;
Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang, CN;
SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., Shanghai, CN;
Abstract
The present application relates to a synthesis method for cariprazine, comprising performing an acylation reaction between a compound represented by formula (I) and dimethylcarbamoyl chloride in a reaction solvent in the presence of an aqueous solution of an inorganic base, so as to obtain the cariprazine compound represented by formula (II). The synthesis method overcomes defects in the prior art such as a long reaction time, large size impurities and the difficulty of purification, and provides a new method suitable for commercial production wherein the reaction is fast, impurity sizes are small, the product is easily purified, the purity of the product can reach 99.0% or more, and the yield is high.