The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Mar. 03, 2022
Applicant:
Nikang Therapeutics, Inc., Wilmington, DE (US);
Assignee:
NIKANG THERAPEUTICS, INC., Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 255/54 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07C 255/54 (2013.01); A61P 35/00 (2018.01); C07C 2603/10 (2017.05);
Abstract
The present disclosure is directed certain Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and their use in the treatment of diseases mediated by HIF-2α such as cancer. Also provided is the use of HIF-2α inhibitors in combination with a poly (ADP-ribose) polymerase (PARP) inhibitor. In particular, the present disclosure is directed to methods for the treatment of cancers using a HIF-2α inhibitor in combination with a PARP inhibitor and pharmaceutical compositions comprising the same.