The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Dec. 04, 2020
Applicant:
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Inventors:
Changming Yang, Zhejiang, CN;
Pan Guo, Zheijang, CN;
Yifeng Wang, Zheijang, CN;
Wenling Zhang, Zheijang, CN;
Peng Wang, Zheijang, CN;
Assignee:
ZHEIJIANG HUAHAI PHARMACEUTICAL CO., LTD., Zhejiang, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 227/06 (2006.01); C12P 13/02 (2006.01);
U.S. Cl.
CPC ...
C07C 227/06 (2013.01); C12P 13/02 (2013.01);
Abstract
A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method. In particular, the method comprises: reacting compound (I) 3-isobutylglutaric acid, as a raw material, with a nitrogen-containing agent to produce compound (II) 3-isobutylglutarimide; and performing stereoselective ring-opening of compound (II) under the action of a biological enzyme to produce compound (III) (R)-3-(carbamoylmethyl)-5-methylhexanoic acid: