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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11419950 B1

PDFFull Text
Date of Patent:
Aug. 23, 2022

Filed:

Dec. 21, 2018

Vectors for liver-directed gene therapy of hemophilia and methods and use thereof

Applicant:

Vrije Universiteit Brussel, Brussels, BE;

Inventors:

Thierry Vandendriessche, Bierbeek, BE;

Marinee Chuah, Bierbeek, BE;

Assignee:

Vrije Universiteit Brussel, Brussels, BE;

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

Maria Marvich

Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/864 (2006.01); C12N 15/12 (2006.01); A61K 48/00 (2006.01); A61K 38/37 (2006.01); A61K 38/36 (2006.01); A61P 1/16 (2006.01); C12N 15/86 (2006.01); A61K 38/16 (2006.01); A61K 38/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 38/16 (2013.01); A61K 38/36 (2013.01); A61K 38/37 (2013.01); A61K 38/4846 (2013.01); A61K 48/005 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2750/14343 (2013.01); C12N 2799/025 (2013.01); C12N 2830/008 (2013.01); C12N 2830/42 (2013.01);
Abstract

The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.

Find Patent Forward Citations

Vandendriessche, Thierry. (2022). Vectors for liver-directed gene therapy of hemophilia and methods and use thereof (U.S. Patent No. 11419950). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11419950

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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