The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Apr. 17, 2019
Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Yue Shen, Pasadena, CA (US);
Sarkis K. Mazmanian, Porter Ranch, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/715 (2006.01); G01N 33/50 (2006.01); C08B 37/00 (2006.01); A61K 39/02 (2006.01); A23L 33/10 (2016.01); A61K 47/69 (2017.01); A61K 9/10 (2006.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/715 (2013.01); A23L 33/10 (2016.08); A61K 9/10 (2013.01); A61K 39/0216 (2013.01); A61K 47/6901 (2017.08); C08B 37/006 (2013.01); C12N 5/0637 (2013.01); G01N 33/505 (2013.01); A61K 9/0065 (2013.01); A61K 2039/542 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55583 (2013.01); A61K 2039/57 (2013.01); A61K 2039/58 (2013.01); G01N 2333/5428 (2013.01);
Abstract
PSA is delivered to the host by outer membrane vesicles (OMVs), secretion structures that target bacterial molecules to host cells. Purified OMVs direct the in vitro differentiation of functional Tregs with potent suppressive activity in a PSA dependent manner. Treatment of animals with OMVs containing PSA prevents experimental colitis and suppresses pro-inflammatory cytokine responses in the gut, and indicate that compositions, medicaments, and methods useful for the treatment of inflammation, and more particularly, inflammatory bowel diseases.