The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Nov. 30, 2018
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Alexander O. Mujica, Elmsford, NY (US);
Yajun Tang, White Plains, NY (US);
Jeffrey D. Lee, New York, NY (US);
Min Gao, Woodcliff Lake, NJ (US);
Susan D. Croll, New Paltz, NY (US);
Lynn Macdonald, Harrison, NY (US);
Ying Hu, Scarsdale, NY (US);
Carmelo Romano, Tarrytown, NY (US);
Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.