The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2022
Filed:
Mar. 18, 2019
Applicants:
Central Institute for Experimental Animals, Kawasaki, JP;
The Board of Regents of the University of Nebraska, Lincoln, NE (US);
Inventors:
Larisa Poluektova, Omaha, NE (US);
Santhi Gorantla, Omaha, NE (US);
Mamoru Ito, Kawasaki, JP;
Ikumi Katano, Kawasaki, JP;
Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
A01K 67/027 (2013.01); A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); C12N 5/0622 (2013.01); A01K 2207/12 (2013.01); A01K 2207/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0337 (2013.01);
Abstract
The present invention provides a non-human animal having human interleukin-34 (IL-34) in the body thereof; a method for producing a non-human animal having human microglia, which includes transplanting human CD34-positive hematopoietic stem cells into the non-human animal having human IL-34 in the body; and a method for producing human microglia, which includes obtaining human microglia from the non-human animal having human microglia.