The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2022
Filed:
Jun. 21, 2019
Applicant:
X-body, Inc., Waltham, MA (US);
Inventors:
Yan Chen, Lexington, MA (US);
Steven M. Shamah, Waltham, MA (US);
Assignee:
X-BODY, INC., Waltham, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 30/04 (2006.01); G01N 33/68 (2006.01); C12N 15/10 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C40B 30/04 (2013.01); C12N 15/1037 (2013.01); G01N 33/6878 (2013.01); C07K 16/28 (2013.01); G01N 2500/04 (2013.01);
Abstract
The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.