The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2022
Filed:
Aug. 25, 2016
Applicant:
Auckland Uniservices Limited, Auckland, NZ;
Inventors:
Brian Desmond Palmer, Auckland, NZ;
Lai-Ming Ching, Auckland, NZ;
Assignee:
Auckland UniServices Limited, Auckland, NZ;
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); A61K 31/437 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/437 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.