The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 16, 2022

Filed:

Feb. 05, 2019
Applicants:

The Rockefeller University, New York, NY (US);

Memorial Sloan-kettering Cancer Center, New York, NY (US);

Inventors:

Lodoe Lama, New York, NY (US);

Thomas Tuschl, New York, NY (US);

Daisuke Tomita, Harrison, NY (US);

Dinshaw Patel, New York, NY (US);

J. Fraser Glickman, New York, NY (US);

Taku Kamei, Kamakura, JP;

Michael Miller, Scotch Plains, NY (US);

Yasutomi Asano, Chigasaki, JP;

Rei Okamoto, Yokohama, JP;

Shogo Hashizume, Yokohama, JP;

Jumpei Aida, Yokohama, JP;

Toshihiro Imaeda, Fujisawa, JP;

Mayako Michino, New York, NY (US);

Takanobu Kuroita, New York, NY (US);

Assignee:

The Rockefeller University, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/407 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 471/04 (2013.01);
Abstract

1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.


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