The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2022
Filed:
Jan. 03, 2020
Ascentage Pharma (Suzhou) Co., Ltd, Suzhou, CN;
Ascentage Pharma Group Corp Limited, Hong Kong, CN;
Ming Guo, Suzhou, CN;
Jianfeng Wen, Suzhou, CN;
Tianzhu Wu, Suzhou, CN;
Huirong Lu, Suzhou, CN;
Feng Xu, Suzhou, CN;
ASCENTAGE PHARMA (SUZHOU) CO., LTD., Suzhou, CN;
ASCENTAGE PHARMA GROUP CORP LIMITED, Hong Kong, CN;
Abstract
The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.