The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Sep. 04, 2019
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventor:
Dasa Lipovsek, Pepperell, MA (US);
Assignee:
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/08 (2006.01); C07K 14/78 (2006.01); A61K 47/64 (2017.01); C40B 40/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/78 (2013.01); A61K 47/6435 (2017.08); C40B 40/08 (2013.01); C07K 2318/20 (2013.01); C40B 40/10 (2013.01);
Abstract
Provided herein are proteins comprising a fibronectin based scaffold (FBS) domain, e.g.,Fn3 molecules, that bind specifically to a target, and wherein the FBS domain is linked at its C-terminus to a region consisting of PmXn, wherein P is proline, X is any amino acid and wherein n is 0 or an integer that is at least 1 and m is an integer that is at least 1, and wherein the PmXn moiety provides an enhanced property to the FBS domain, e.g., enhanced stability, relative to the protein that is not linked to the PmXn moiety.