The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Apr. 22, 2019
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Aimee S. Payne, Merion Station, PA (US);
Christoph T. Ellebrecht, Philadelphia, PA (US);
Vijay Bhoj, Philadelphia, PA (US);
Michael C. Milone, Cherry Hill, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.