The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Jun. 29, 2017
Graybug Vision, Inc., Redwood City, CA (US);
Hans-Gottfried Genieser, Lemwerder, DE;
Frank Schwede, Bremen, DE;
Andreas Rentsch, Bremen, DE;
Per Ekström, Lund, SE;
Valeria Marigo, Modena, IT;
Francois Paquet-Durand, Tübingen, DE;
Graybug Vision, Inc., Redwood City, CA (US);
Abstract
Embodiments of the invention are directed to new equatorially modified polymer linked multimers of guanosine-3', 5′-cyclic monophosphate (cGMP) analogues that inhibit the cGMP-signaling system. The invention is also directed to related monomeric compounds, which may serve as monomeric precursors of the multimers, and/or also show itself inhibitory activity and/or impact the inhibitory activity of the related multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications, e.g., on chip surfaces.