The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Sep. 21, 2018
Applicant:
The University of Nottingham, Nottingham, GB;
Inventors:
David Brook, Nottingham, GB;
Chris Hayes, Nottingham, GB;
Nicholas Bennett, Nottingham, GB;
Matthew Palframan, Nottingham, GB;
Sue Cramp, Essex, GB;
Richard Bull, Essex, GB;
Michael Bodnarchuk, Essex, GB;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); A61K 31/437 (2006.01); A61P 33/02 (2006.01); A61P 35/04 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61P 33/02 (2018.01); A61P 35/04 (2018.01); C07D 471/04 (2013.01);
Abstract
This invention related to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by the CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular, the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R, R, R, R, Rand Rare as defined herein.