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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11407763 B1

PDFFull Text
Date of Patent:
Aug. 09, 2022

Filed:

Aug. 24, 2018

Tryptophan hydroxylase inhibitor and pharmaceutical composition including same

Applicants:

Gwangju Institute of Science and Technology, Gwangju, KR;

Korea Advanced Institute of Science and Technology, Daejeon, KR;

Kyungpook National University Industry-academic Cooperation Foundation, Daegu, KR;

Curacle Co., Ltd., Seongnam-si, KR;

Inventors:

Jin Hee Ahn, Gwangju, KR;

Hail Kim, Daejeon, KR;

Jaemyoung Suh, Daejeon, KR;

In-Kyu Lee, Daegu, KR;

Kwang-eun Kim, Yuseong-gu Daejeon, KR;

Kun-Young Park, Daejeon, KR;

Eun Jung Bae, Gwangju, KR;

Ko Eun Shong, Daejeon, KR;

Suvarna Haus-habhau Pagire, Gwangju, KR;

Ajin Lim, Daejeon, KR;

Jae-Han Jeon, Daegu, KR;

Haushabhau Shivaji Pagire, Gwangju, KR;

Haiying Zhang, Seongnam-si, KR;

Myung-Hwa Kim, Seongnam-si, KR;

Jung-In Pyo, Seongnam-si, KR;

Assignees:

Gwangju Institute of Science and Technolgy, Gwangju, KR;

Korea Advanced Institute of Science and Technology, Daejeon, KR;

KyungPook National University Industry-Academic Cooperation Foundation, Daegu, KR;

Curacle Co., LTD., Gyeonggi-Do, KR;

Attorney:

Workman Nydegger

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07D 487/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 271/06 (2006.01); C07D 231/12 (2006.01); C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 239/47 (2006.01); C07D 405/12 (2006.01); C07D 403/08 (2006.01); A61P 35/00 (2006.01); A61P 1/00 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61P 1/00 (2018.01); A61P 35/00 (2018.01); C07D 231/12 (2013.01); C07D 239/47 (2013.01); C07D 271/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/08 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.

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