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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11406717 B1

PDFFull Text
Date of Patent:
Aug. 09, 2022

Filed:

Apr. 14, 2017

Adeno-associated virus vector delivery of microrna-29 and micro-dystrophin to treat muscular dystrophy

Applicant:

Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);

Inventors:

Louise Rodino-Klapac, E. Groveport, OH (US);

Jerry R. Mendell, Columbus, OH (US);

Kristin N. Heller, Columbus, OH (US);

Assignee:

RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US);

Attorney:

Marshall, Gerstein & Borun LLP

Primary Examiner:

Kimberly Chong

Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61K 31/7088 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/86 (2006.01); A61P 21/00 (2006.01); A61K 9/00 (2006.01); A61P 19/04 (2006.01); A61K 35/761 (2015.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 9/0019 (2013.01); A61K 31/7088 (2013.01); A61K 35/761 (2013.01); A61K 38/1709 (2013.01); A61K 38/1719 (2013.01); A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); A61P 19/04 (2018.01); A61P 21/00 (2018.01); C07K 14/4708 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); C12N 15/8645 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/22 (2013.01); C12N 2830/008 (2013.01);
Abstract

The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from dystrophinopathy or muscular dystrophy. The invention also provides for combination therapies comprising expressing both miR-29 and micro-dystrophin to reduce and prevent fibrosis in patients suffering from dystrophinopathy or muscular dystrophy.

Find Patent Forward Citations

Rodino-Klapac, Louise. (2022). Adeno-associated virus vector delivery of microrna-29 and micro-dystrophin to treat muscular dystrophy (U.S. Patent No. 11406717). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11406717

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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