logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11406710 B1

PDFFull Text
Date of Patent:
Aug. 09, 2022

Filed:

Sep. 07, 2018

Constrained conditionally activated binding proteins

Applicant:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

Chad May, Belmont, CA (US);

Robert B. Dubridge, Belmont, CA (US);

Maia Vinogradova, Moraga, CA (US);

Anand Panchal, San Francisco, CA (US);

Assignee:

TAKEDA PHARMACEUTICAL COMPANY LIMITED, Osaka, JP;

Attorneys:

Jeffry S. Mann

Andrew J. Antczak

Morgan, Lewis & Bockius LLP

Primary Examiner:

Lisa V Cook

Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); A61P 35/00 (2006.01); C07K 16/46 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/2827 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/62 (2013.01); C07K 2317/622 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/50 (2013.01);
Abstract

The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.

Find Patent Forward Citations

May, Chad. (2022). Constrained conditionally activated binding proteins (U.S. Patent No. 11406710). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11406710

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…