The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Jun. 08, 2020
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Lan Zhang, Chalfont, PA (US);
Zhiyun Wen, Devon, PA (US);
Craig T. Przysiecki, Kintnersville, PA (US);
Ping Qiu, Cranbury, NJ (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
The present invention relates to methods for the recombinant expression ofmajor outer membrane protein (MOMP) comprising transforming a population ofhost cells with an expression vector comprising a nucleic acid molecule that encodesMOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis ofinfection and/or the effects thereof.