The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
Sep. 30, 2019
Biomarin Pharmaceutical Inc., Novato, CA (US);
Ucl Business Plc, London, GB;
St. Jude Children's Research Hospital, Memphis, TN (US);
Peter Cameron Colosi, Novato, CA (US);
Amit Nathwani, London, GB;
Jenny McIntosh, London, GB;
Edward Tuddenham, London, GB;
Andrew Davidoff, Memphis, TN (US);
BIOMARIN PHARMACEUTICAL INC., Novato, CA (US);
UCL BUSINESS LTD, London, GB;
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, Memphis, TN (US);
Abstract
The present disclosure provides methods of generating multiplexed genetically modified animals, for example, porcine endogenous retrovirus (PERV)-inactivated pigs. The disclosure also provides methods of improving the birth rate of multiplexed genetically modified animals. In some embodiments, the present closure is concerned with the generation and utilization of porcine cells in which porcine endogenous retroviral (PERV) elements have been inactivated. In sonic embodiments, the PERV-free or PERV-reduced porcine cells are cloned to produce porcine embryos. In some embodiments, the PERV-free or PERV-reduced embryos may be grown into adult swine from which organs and/or tissues may be extracted and used for such purposes as xenotransplantation into non-porcine animals such as humans.