The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2022
Filed:
May. 02, 2017
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Sorbonne Universite, Paris, FR;
Universite Paris Descartes, Paris, FR;
Assistance Publique-hopitaux DE Paris (Aphp), Paris, FR;
INSERM (Institut National de la Santé et de la Recherche Médicale), Paris, FR;
Sorbonne Université, Paris, FR;
Université Paris Descartes, Paris, FR;
Assistance Publique-Hôpitaux de Paris (APHP), Paris, FR;
Abstract
The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call 'fetal myeloid progenitor cells' (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.