IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11406646 B1

PDFFull Text
Date of Patent:
Aug. 09, 2022

Filed:

Nov. 10, 2020

Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Applicants:

Virginia Commonwealth University, Richmond, VA (US);

Durect Corporation, Cupertino, CA (US);

Inventors:

Shunlin Ren, Richmond, VA (US);

Leyuan Xu, Richmond, VA (US);

Yanxia Ning, Richmond, VA (US);

Jin Koung Kim, Richmond, VA (US);

WeiQi Lin, Emerald Hills, CA (US);

Andrew R. Miksztal, Palo Alto, CA (US);

Hongwei Wu, Cupertino, CA (US);

Min L. Lee, Saratoga, CA (US);

Assignees:

Virginia Commonwealth University, Richmond, VA (US);

Durect Corporation, Cupertino, CA (US);

The United States Government as Represented by The Department of Veterans Affairs, Washington, DC (US);

Attorneys:

Khin K. Chin

Bozicevic Field & Francis LLP

Primary Examiner:

Leigh C Maier

Int. Cl.
CPC ...
A61K 31/565 (2006.01); A61P 1/16 (2006.01); A61K 31/724 (2006.01); A61K 47/10 (2017.01); A61K 31/575 (2006.01); A61K 47/40 (2006.01); A61P 17/06 (2006.01); A61P 3/06 (2006.01); A61P 31/04 (2006.01); A61Q 19/00 (2006.01); A61K 8/73 (2006.01); A61K 9/19 (2006.01); A61K 9/00 (2006.01); A61K 8/63 (2006.01); C07J 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/565 (2013.01); A61K 8/63 (2013.01); A61K 8/738 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 31/575 (2013.01); A61K 31/724 (2013.01); A61K 47/10 (2013.01); A61K 47/40 (2013.01); A61P 1/16 (2018.01); A61P 3/06 (2018.01); A61P 17/06 (2018.01); A61P 31/04 (2018.01); A61Q 19/00 (2013.01); A61Q 19/004 (2013.01); A61Q 19/007 (2013.01); C07J 31/006 (2013.01);
Abstract

Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.

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